The relativity of biological function

TitleThe relativity of biological function
Publication TypeJournal Article
Year of Publication2015
AuthorsLaubichler Manfred D., Stadler Peter F., Prohaska Sonja J., and Nowick Katja
JournalTheory in Biosciences
Volume134
Pagination143–147
Date Published12
ISSN1431-7613
KeywordsBiological function, Biological theory, Coarse graining, ENCODE, Theory integration
Abstract

Function is a central concept in biological theories and explanations. Yet discussions about function are often based on a narrow understanding of biological systems and processes, such as idealized molecular systems or simple evolutionary, i.e., selective, dynamics. Conflicting conceptions of function continue to be used in the scientific literature to support certain claims, for instance about the fraction of “functional DNA” in the human genome. Here we argue that all biologically meaningful interpretations of function are necessarily context dependent. This implies that they derive their meaning as well as their range of applicability only within a specific theoretical and measurement context. We use this framework to shed light on the current debate about functional DNA and argue that without considering explicitly the theoretical and measurement contexts all attempts to integrate biological theories are prone to fail.

DOI10.1007/s12064-015-0215-5